BDBM50200391 CHEMBL3928531::US9763922, Example 214

SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CCC#N

InChI Key InChIKey=NZAWVJDDBLNIQI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50200391   

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200391(CHEMBL3928531 | US9763922, Example 214)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM50200391(CHEMBL3928531 | US9763922, Example 214)
Affinity DataIC50: 220nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50200391(CHEMBL3928531 | US9763922, Example 214)
Affinity DataIC50: 220nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200391(CHEMBL3928531 | US9763922, Example 214)
Affinity DataIC50: 1.46E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
Go to US Patent