BDBM50200369 CHEMBL3915620

SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1

InChI Key InChIKey=FHRWHNJJQGSCQC-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 Kd  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50200369   

TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  233nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2018
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  233nMAssay Description:Agonist activity at FFA1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  9.10nMAssay Description:Agonist activity at human GPR40 receptor expressed in HEK293 cells assessed as increase in intracellular calcium flux after 2.5 hrs measured over 3 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  134nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-8 dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  9.10nMAssay Description:Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  8.70nMAssay Description:Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  0.850nMAssay Description:Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arresti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  2nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataKd:  2.5nMAssay Description:Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human Gal4-fused PPARalpha LBD expressed in African green monkey CV1 cells cotransfected with pRL-SV40 plasmid measured after 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human Gal4-fused PPARdelta LBD expressed in African green monkey CV1 cells cotransfected with pRL-SV40 plasmid measured after 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human CMV-fused PPARgamma LBD/RXRalpha (unknown origin) expressed in African green monkey CV1 cells transfected with luciferase p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataKi:  4.70nMAssay Description:Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50200369(CHEMBL3915620)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed