BDBM50199786 CHEMBL3918282

SMILES OC(CN1CCN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1

InChI Key InChIKey=MACFTPBZAOCTFN-UHFFFAOYSA-N

Data  16 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50199786   

TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute on Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  0.806nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat striatal membranes incubated for 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute on Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute on Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute on Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  12nMAssay Description:Inhibition of DAT (unknown origin) expressed in COS7 cells assessed as reduction in [3H]DA uptake incubated for 5 mins by beta-scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
National Institute On Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  42nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]N-methylspiperone from human D2R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
National Institute On Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  336nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in whole-guinea pig brain minus cerebellum homogenates incubated for 120 mins by radioligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  652nMAssay Description:Displacement of [3H]N-methylspiperone from human D3R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  652nMAssay Description:Displacement of [3H]-N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by microbeta scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  1.75E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D4R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  1.75E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from human D4.4 receptor expressed in HEK293 cell membranes measured after 60 mins by microbeta scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  4.61E+3nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain stem membranes incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50199786(CHEMBL3918282)
Affinity DataKi:  1.27E+4nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat midbrain membranes incubated for 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed