BDBM50199735 CHEMBL388879::methotrexate gamma-L-proline-hydroxamic acid

SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)NO)C(O)=O

InChI Key InChIKey=UYVVHTPVCDOQRA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50199735   

TargetDihydrofolate reductase(Human)
Instituto Superior T£Cnico

Curated by ChEMBL
LigandPNGBDBM50199735(methotrexate gamma-L-proline-hydroxamic acid | CHE...)
Affinity DataIC50: 130nMAssay Description:Inhibition of DHFR using folic acid substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Instituto Superior T£Cnico

Curated by ChEMBL
LigandPNGBDBM50199735(methotrexate gamma-L-proline-hydroxamic acid | CHE...)
Affinity DataIC50: 120nMAssay Description:Inhibition of DHFR using dihydrofolic acid substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed