BDBM50199731 CHEMBL244883::methotrexate gamma-hydroxamic acid

SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)NO)C(O)=O

InChI Key InChIKey=YUQBNZUBNMWBAQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50199731   

TargetDihydrofolate reductase(Human)
Instituto Superior T£Cnico

Curated by ChEMBL
LigandPNGBDBM50199731(methotrexate gamma-hydroxamic acid | CHEMBL244883)
Affinity DataIC50: 70nMAssay Description:Inhibition of DHFR using dihydrofolic acid substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Instituto Superior T£Cnico

Curated by ChEMBL
LigandPNGBDBM50199731(methotrexate gamma-hydroxamic acid | CHEMBL244883)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Instituto Superior T£Cnico

Curated by ChEMBL
LigandPNGBDBM50199731(methotrexate gamma-hydroxamic acid | CHEMBL244883)
Affinity DataIC50: 170nMAssay Description:Inhibition of DHFR using folic acid substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed