BDBM50199622 3-cyclobutyl-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine::CHEMBL245408::US8481733, Comparator 5

SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCC1

InChI Key InChIKey=XHSJLIVIOWHYQO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50199622   

TargetActivated CDC42 kinase 1(Human)
Osi Pharmaceuticals

US Patent
LigandPNGBDBM50199622(CHEMBL245408 | US8481733, Comparator 5 | 3-cyclobu...)
Affinity DataIC50: 148nMAssay Description:Compounds of the invention were tested for ACK1 inhibition activity. 1 uL compounds prepared at 15× in 4 mM DMSO were combined with 9 uL ATP so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2013
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199622(CHEMBL245408 | US8481733, Comparator 5 | 3-cyclobu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-IGF1R activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Osi Pharmaceuticals

US Patent
LigandPNGBDBM50199622(CHEMBL245408 | US8481733, Comparator 5 | 3-cyclobu...)
Affinity DataIC50: 190nMAssay Description:Inhibition of ACK1 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed