BDBM50198492 CHEMBL217860::N-[(2S)-6-[(1,1-dioxo-1,4-thiomorpholin-4-yl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)-N-methylbenzamid

SMILES CN([C@H]1CCc2cc(CN3CCS(=O)(=O)CC3)ccc2C1)C(=O)c1ccc(cc1)-c1ccc(F)cc1

InChI Key InChIKey=VRLORRTWDYVKNM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50198492   

Target5-hydroxytryptamine receptor 2C(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198492(N-[(2S)-6-[(1,1-dioxo-1,4-thiomorpholin-4-yl)methy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of binding to serotonin receptor 5HT2CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50198492(N-[(2S)-6-[(1,1-dioxo-1,4-thiomorpholin-4-yl)methy...)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50198492(N-[(2S)-6-[(1,1-dioxo-1,4-thiomorpholin-4-yl)methy...)
Affinity DataKi:  755nMAssay Description:Functional antagonism of MCH-R1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed