BDBM50198118 (2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-acetamido-1,3-thiazol-4-yl)-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide::CHEMBL397948

SMILES CC(=O)Nc1nc(cs1)[C@H](CCN1CCC2(CC1)C=Cc1ccccc21)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=JRZCODWVRVCQHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50198118   

TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50198118((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50198118((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of MCP1-stimulated chemotaxis in monocytes transfected with human CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed