BDBM50197526 CHEMBL3982647

SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)NC(=O)[C@H](CC1CCCCC1)NS(=O)(=O)N[C@@H](CCCCN)C(O)=O

InChI Key InChIKey=IQHARPQKKWCGEY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50197526   

TargetCytochrome P450 3A4(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50197526(CHEMBL3982647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as suppression of 1'-hydroxymidazolam formation after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50197526(CHEMBL3982647)
Affinity DataIC50: 123nMAssay Description:Inhibition of activated TAFI in human blood by clot lysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50197526(CHEMBL3982647)
Affinity DataIC50: 51nMAssay Description:Inhibition of activated human plasma TAFI incubated for 15 mins in presence of 1% human serum albumin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50197526(CHEMBL3982647)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as suppression of 1'-hydroxymidazolam formation after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
LigandPNGBDBM50197526(CHEMBL3982647)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed