BDBM50196631 CHEMBL3898722::US10167270, Compound 7i

SMILES C(CC1CCCCC1)Nc1nc(nc2ccccc12)-c1cccnc1

InChI Key InChIKey=HDBYPZURDNCVJI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50196631   

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196631(CHEMBL3898722 | US10167270, Compound 7i)
Affinity DataIC50: 857nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196631(CHEMBL3898722 | US10167270, Compound 7i)
Affinity DataIC50: 282nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196631(CHEMBL3898722 | US10167270, Compound 7i)
Affinity DataIC50: 857nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent