BDBM50196531 CHEMBL3964444::US10167270, Compound 7a

SMILES C1CCCC(CCC1)Nc1nc(nc2ccccc12)-c1cccnc1

InChI Key InChIKey=KPHDEGYZCGJLCL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50196531   

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196531(CHEMBL3964444 | US10167270, Compound 7a)
Affinity DataIC50: 27nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196531(CHEMBL3964444 | US10167270, Compound 7a)
Affinity DataIC50: 28nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196531(CHEMBL3964444 | US10167270, Compound 7a)
Affinity DataIC50: 27nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University Feinberg School of Medicine

Curated by ChEMBL
LigandPNGBDBM50196531(CHEMBL3964444 | US10167270, Compound 7a)
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type recombinant human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed