BDBM50196040 1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-benzylurea::CHEMBL385175

SMILES CN(Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccc3)c(=O)c12)-c1ccc(NC(=O)NCc2ccccc2)cc1)Cc1ccccc1

InChI Key InChIKey=POAHYXZXLSZBDG-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50196040   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 600nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR H306A mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR D302A mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 900nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR F309L mutant expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 30nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR N27A mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 390nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR M24I mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 500nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR D302N mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 190nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR L300A mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 70nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR Q208E mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR F309Q mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR F313L mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 20nMAssay Description:Displacement of [125I]-His5, D-Tyr6]GnRH from GnRHR F272L mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR H306E mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 6.00E+3nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR Y284L mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50196040(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 70nMAssay Description:Displacement of [His5, D-Tyr6]GnRH from GnRHR Y290L mutant expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed