BDBM50195655 CHEMBL383896::N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3'-butenamino]-7,8-dihydronormorphinone

SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35NCC\C=C\c1ccc(Cl)cc1

InChI Key InChIKey=LHHZTZQOZGGGTA-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50195655   

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataIC50: 1.20nMAssay Description:Activity at human recombinant delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]U-69593 from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataIC50: 17nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed