BDBM50195432 CHEMBL3957478

SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(N)c(F)c(C)c1Cl)C(=O)Oc1ccccc1

InChI Key InChIKey=VKUIARDCYFJGLG-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50195432   

TargetHistone-lysine N-methyltransferase 2A/Retinoblastoma-binding protein 5/Set1/Ash2 histone methyltransferase complex subunit ASH2/WD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50195432(CHEMBL3957478)Copy SMILESCopy InChI

Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/9/2018
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50195432(CHEMBL3957478)Copy SMILESCopy InChI

Affinity DataIC50: 26nMAssay Description:Inhibition of C-terminal 5-FAM-ARTEVHLRKS binding to WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/9/2018
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL