BDBM50195263 CHEMBL3942969::US10287258, Example 33::US10669245, Example 33::US11117874, Example 33::US11673871, Example 33::US11680049, Example 33::US20230278969, Example 33

SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1

InChI Key InChIKey=MUTKXUKCDAFWLB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50195263   

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195263(CHEMBL3942969 | US10287258, Example 33 | US1066924...)
Affinity DataIC50: 61.7nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent