BDBM50195238 CHEMBL3962926::US10287258, Example 20::US10669245, Example 20::US11117874, Example 20::US11655221, Example 20::US11680049, Example 20::US20230278969, Example 20

SMILES CN1C(=O)COc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1

InChI Key InChIKey=QKDQSHLZLZUQOA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50195238   

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 13nMAssay Description:Inhibition of DPP1 in human U937 cells using Gly-Phe-AFC as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195238(CHEMBL3962926 | US10287258, Example 20 | US1066924...)
Affinity DataIC50: 12.6nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent