BDBM50195236 CHEMBL3927609::US10287258, Example 1::US10669245, Example 1::US11117874, Example 1::US11673871, Example 34::US11680049, Example 1::US20230278969, Example 1

SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CNCCCO1

InChI Key InChIKey=FCRODBUNBQJNPU-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50195236   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 32nMAssay Description:Inhibition of DPP1 in human U937 cells using Gly-Phe-AFC as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 60.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195236(CHEMBL3927609 | US10287258, Example 1 | US10669245...)
Affinity DataIC50: 35.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent