BDBM50194193 CHEMBL3926051

SMILES Cc1cccc2ccc(nc12)N1CC[C@H](C(=O)N[C@H]2CCOC2)C(C)(C)C1

InChI Key InChIKey=GHLMLJMEPBTLPT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50194193   

TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194193(CHEMBL3926051)
Affinity DataIC50: 6nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194193(CHEMBL3926051)
Affinity DataIC50: 23nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in recombinant human interleukin-1 beta-induced PGE2 production preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194193(CHEMBL3926051)
Affinity DataIC50: 51nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed