BDBM50194084 9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one::CHEMBL214972

SMILES Oc1ccc(cc1)C1=C2c3ccc(O)cc3CC2(Cc2ccccc2)CCC1=O

InChI Key InChIKey=PLRCLQGHUZGZQN-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194084   

TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)
Affinity DataIC50: 29nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)
Affinity DataEC50:  11nMAssay Description:Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)
Affinity DataIC50: 100nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)
Affinity DataIC50: 220nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed