BDBM50194082 9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one::CHEMBL424725

SMILES O=C1CCC2(Cc3ccccc3)Cc3c(ccc4n[nH]cc34)C2=C1c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=QVVZKGBRCGNLJU-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194082   

TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)
Affinity DataIC50: 110nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)
Affinity DataIC50: 620nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)
Affinity DataEC50:  300nMAssay Description:Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)
Affinity DataIC50: 130nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed