BDBM50194075 9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-ylethoxy)phenyl]-1,2,9,9a-tetrahydro-3H-fluoren-3-one::CHEMBL209530

SMILES Oc1ccc2C3=C(C(=O)CCC3(Cc3ccc(Cl)cc3)Cc2c1)c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=YHOXIEXEPIIKMD-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194075   

TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194075(9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-...)
Affinity DataEC50:  41nMAssay Description:Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194075(9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-...)
Affinity DataIC50: 29nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194075(9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194075(9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed