BDBM50194066 5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-3-4-methylpiperazin-1-yl)propyl)isothiazole-4-carboximidamide::CHEMBL386457

SMILES CN1CCN(CCCN=C(N)c2c(Nc3ccc(Oc4cc(Cl)ccc4Cl)cc3)s[nH]c2=O)CC1

InChI Key InChIKey=DKNBBJIUOACTGI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50194066   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194066(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-3...)
Affinity DataEC50:  605nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194066(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-3...)
Affinity DataIC50: 298nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed