BDBM50194024 3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxyphenylamino)isothiazole-4-carboximidamide::CHEMBL437331

SMILES CC(CO)N=C(N)c1c(Nc2ccc(Oc3ccccc3)cc2)s[nH]c1=O

InChI Key InChIKey=QDWSVWMOWVHELW-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50194024   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 33nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataEC50:  42nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 26nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 795nMAssay Description:Inhibition of Flt-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 142nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1/beta-2(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 2.62E+3nMAssay Description:Inhibition of p70 S6 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 260nMAssay Description:Inhibition of AuroraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 455nMAssay Description:Inhibition of AxlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed