BDBM50193836 1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-phenylethanone::CHEMBL373821

SMILES O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1

InChI Key InChIKey=QXRXXIKAVZAGHZ-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50193836   

TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human MC4R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human MC1R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50193836(1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazi...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed