BDBM50193822 CHEMBL3972807

SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc3C[C@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl)C(N)=O

InChI Key InChIKey=ACYSIZUFQATBIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50193822   

TargetInsulin receptor(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193822(CHEMBL3972807)
Affinity DataIC50: 403nMAssay Description:Inhibition of recombinant human INSR expressed in baculovirus using ATP as substrate after 15 mins by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193822(CHEMBL3972807)
Affinity DataIC50: 30nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193822(CHEMBL3972807)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193822(CHEMBL3972807)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed