BDBM50193112 CHEMBL3966536

SMILES CNCCOc1ccc(cc1)-c1sc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1C)-c1cccs1

InChI Key InChIKey=PLXMEYFSSFOKSR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50193112   

TargetTyrosine-protein kinase ABL1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50193112(CHEMBL3966536)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of recombinant human ABL1 expressed in insect cells preincubated for 15 mins followed by poly(Glu:Tyr) substrate addition for 30 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50193112(CHEMBL3966536)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human FLT3 expressed in insect Sf21 cells preincubated for 15 mins followed by poly(Glu:Tyr) substrate addition for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50193112(CHEMBL3966536)
Affinity DataIC50: 9.75E+3nMAssay Description:Inhibition of human TIE2 preincubated for 15 mins followed by substrate addition measured after 30 mins in presence of [gamma-32P]ATP by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50193112(CHEMBL3966536)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human wild-type FLT3 (564 to end residues) expressed in baculovirus infected sf21 cells using Abltide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2019
Entry Details Article
PubMed