BDBM50192668 CHEMBL1684950::US20240190865, Example 56

SMILES CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1

InChI Key InChIKey=IQIKXZMPPBEWAD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50192668   

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human T-type calcium channel Cav3.1 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of CaV 3.2 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of CaV 3.3 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CaV 3.1 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human T-type calcium channel Cav3.2 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human T-type calcium channel Cav3.3 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192668(CHEMBL1684950 | US20240190865, Example 56)
Affinity DataIC50: 37nMAssay Description:HEK293 cells were cultured in Dulbecco's Modified Eagle Medium/Nutrient Mixture F-12 (D-MEM/F-12) supplemented with 10% fetal bovine serum, 100 U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
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