BDBM50192294 1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-hydroxy-propenyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione::CHEMBL379255

SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O

InChI Key InChIKey=PPSMYMVWZXRNAT-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192294   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50192294(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50192294(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50192294(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataEC50:  6.60E+3nMAssay Description:Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50192294(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataEC50: >2.00E+3nMAssay Description:Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed