BDBM50191981 CHEMBL3979322

SMILES CN1CCN(CC1)c1ccccc1CNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(ccn23)-c2ccnn2C)c1

InChI Key InChIKey=HGVCCQWKRNIKPZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50191981   

TargetPlatelet-derived growth factor receptor beta(Rat)
Novartis Institutes of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191981(CHEMBL3979322)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of PDGFR-beta driven proliferation of rat A10 cells after 68 hrs in presence of rat recombinant PDGF-BB by cell titer-glo luminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2018
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institutes of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191981(CHEMBL3979322)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191981(CHEMBL3979322)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2018
Entry Details Article
PubMed