BDBM50191962 3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-1H-pyrrole-2-carboxylic acid::CHEMBL385220

SMILES CSc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=XVQDUFDWJSXDDR-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50191962   

TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  394nMAssay Description:Activity against human GLUR4 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  474nMAssay Description:Activity against human GLUR2 flop expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  473nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  174nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  394nMAssay Description:Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activity against human GLUR4 flop expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  174nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed