BDBM50191959 3-(4-tert-butylphenyl)-4-cyano-5-(methylthio)thiophene-2-carboxylic acid::3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid::CHEMBL213197

SMILES CSc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=CVJPWFPVQGXTIK-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50191959   

TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  97nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  309nMAssay Description:Activity against human GLUR2 flop expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  1.56E+3nMAssay Description:Activity against human GLUR4 flop expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  214nMAssay Description:Activity against human GLUR4 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  214nMAssay Description:Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  309nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  1.56E+3nMAssay Description:Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  97nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed