BDBM50191470 CHEMBL3967778

SMILES Cc1ncc2sc(nn12)C(=O)N1CCC[C@@H]1c1ccc(Cl)cc1

InChI Key InChIKey=SAVNWXMDAMFANR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191470   

TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191470(CHEMBL3967778)
Affinity DataIC50: 110nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191470(CHEMBL3967778)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed