BDBM50191469 CHEMBL3895703

SMILES CNc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1

InChI Key InChIKey=CUQBBHUITNFLKO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191469   

TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191469(CHEMBL3895703)
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191469(CHEMBL3895703)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed