BDBM50191405 (2'Z,3'E)-7-bromoindirubin-3'-oxime::CHEMBL373834

SMILES Oc1[nH]c2c(Br)cccc2c1-c1[nH]c2ccccc2c1N=O

InChI Key InChIKey=HYMACPDEJIEMST-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50191405   

TargetGlycogen synthase kinase-3 beta(Pig)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of porcine brain GSK3beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant GST-fused DYRK2 expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Pig)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human recombinant aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase C(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant aurora C kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of mammalian CDK5/p25More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50191405((2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834)
Affinity DataIC50: 2.00E+4nMAssay Description:Survival of mouse AhR +/+ 5L cells after 48 hrs by MTS reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed