BDBM50191061 CHEMBL3893653

SMILES CN1CCN(CC1)c1ccc2c(C(=O)NCC(N3CCC(F)(F)CC3)c3cnc(nc3)C(F)(F)F)c(Cl)ccc2n1

InChI Key InChIKey=VVUBBYDXKYZDQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191061   

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191061(CHEMBL3893653)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50191061(CHEMBL3893653)
Affinity DataIC50: 486nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed