BDBM50190913 CHEMBL3912682

SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)c1c(Cl)ccc2nc(ccc12)N1CCOCC1)N1CCC(F)(F)CC1

InChI Key InChIKey=LVKUHHOSWYDRAO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50190913   

TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 103nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human P2X7 receptor assessed as reduction in calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 376nMAssay Description:Antagonist activity at P2X7 receptor in human whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-stimulate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50190913(CHEMBL3912682)
Affinity DataIC50: 631nMAssay Description:Antagonist activity at P2X7 receptor in C57/bl6 mouse whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed