BDBM50190610 (2R,4S,5S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-amino]-tetrahydro-pyran-4-ol::CHEMBL379716

SMILES O[C@H]1C[C@@H](OC[C@@H]1NCc1ccc2[nH]ccc2c1)C(c1ccccc1)c1ccccc1

InChI Key InChIKey=OQKKLDHMNWLVNH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50190610   

TargetTransporter(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50190610((2R,4S,5S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-a...)
Affinity DataKi:  13nMAssay Description:Inhibition of NET-mediated [3H]NE uptake in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50190610((2R,4S,5S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-a...)
Affinity DataKi:  184nMAssay Description:Inhibition of DAT-mediated [3H]DA uptake in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50190610((2R,4S,5S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-a...)
Affinity DataKi:  223nMAssay Description:Inhibition of SERT-mediated [3H]5-HT uptake in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50190610((2R,4S,5S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-a...)
Affinity DataKi:  399nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat striatum DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed