BDBM50190551 1-[2-(tert-butyldimethylsilyloxyethoxy)methyl]uracil::CHEMBL213682

SMILES CC(C)(C)[Si](C)(C)OCCOCn1ccc(=O)[nH]c1=O

InChI Key InChIKey=STXDHUSBXJTEGB-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50190551   

LigandPNGBDBM50190551(1-[2-(tert-butyldimethylsilyloxyethoxy)methyl]urac...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50190551(1-[2-(tert-butyldimethylsilyloxyethoxy)methyl]urac...)
Affinity DataKi:  4.40E+4nMAssay Description:Inhibition of Plasmodium falciparum dUTPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190551(1-[2-(tert-butyldimethylsilyloxyethoxy)methyl]urac...)
Affinity DataKi:  6.30E+4nMAssay Description:Inhibition of human recombinant dUTPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed