BDBM50190523 1-butyl-9-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3-isobutyl-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride::9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride::CHEMBL540366

SMILES CCCCN1C(=O)C(CC(C)C)NC(=O)C11CCN(Cc2ccc3OCCOc3c2)CC1

InChI Key InChIKey=OYYLRSIEFZQBJI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50190523   

TargetC-C chemokine receptor type 5(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity against human recombinant CCR2 expressed in CHO cells assessed as inhibition of human MCP1-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 20nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of radio-isotope labeled MCP1 binding to human recombinant CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of radio-isotope labeled SDF1-alpha binding to human recombinant CXCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190523(9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity against human recombinant CXCR4 expressed in CHO cells assessed as inhibition of human SDF1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed