BDBM50189842 2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo[1,2-a]pyridine::CHEMBL212370

SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1

InChI Key InChIKey=NSWRCNIUQFRZFO-UHFFFAOYSA-N

Data  9 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50189842   

TargetD(4) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataEC50:  2.60nMAssay Description:Activity at human D4.4 receptor expressed in CHOK1 cells assessed as stimulation of [35S]GTP-gammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataEC50:  1.80nMAssay Description:Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  7nMAssay Description:Agonist activity at dopamine D4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  7nMAssay Description:Agonist activity at dopamine D4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Pig)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Pig)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  6.70E+3nMAssay Description:Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  8.80E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50189842(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed