BDBM50189603 CHEMBL377734::N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide

SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1

InChI Key InChIKey=CUPLTRAPYIXFAX-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50189603   

TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SRPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 40nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 370nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PDGFR betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MEKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Her2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKCzetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GSK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Her1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 400nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha/beta/delta/gamma(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CaMK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 40nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamin...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PKCetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed