BDBM50188597 CHEMBL18688

SMILES Oc1nc(nc2ccccc12)-c1ccc(F)cc1

InChI Key InChIKey=IXMXCFSRQIHRHB-UHFFFAOYSA-N

Data  4 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50188597   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 781nMAssay Description:Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 4.69E+3nMAssay Description:Inhibition of human PARP-2 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Jiangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP1B1 (unknown origin) by EROD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A1(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP1A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Jiangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataKi:  7.03E+5nMAssay Description:Mixed-type reversible inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate by Lineweaver-Burk double reciprocal-plot a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Jiangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataKi:  2.22E+5nMAssay Description:Mixed-type reversible inhibition of diphenolase activity of mushroom tyrosinase assessed as enzyme-substrate complex using L-DOPA as substrate by Lin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]DPCPX from Sprague-Dawley rat whole brain membrane A1AR by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
North-West University

Curated by ChEMBL
LigandPNGBDBM50188597(CHEMBL18688)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]NECA from Sprague-Dawley rat striatal membrane A2A adenosine receptor by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed