BDBM50188478 CHEMBL210461::N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][2.2]-paracyclophane-4-carboxamide

SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4CCc5ccc(CCc3cc4)cc5)CC2)c1Cl

InChI Key InChIKey=ACKGCCXJFAZCFF-UHFFFAOYSA-N

Data  6 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50188478   

TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataEC50:  110nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]spiperone from human D4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]spiperone from human D2 short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]spiperone from human D2 long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataKi:  660nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor of porcine cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50188478(N-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl]butyl][...)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed