BDBM50188390 4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentamethyl-7,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid::CHEMBL211039

SMILES CC(CCC(O)=O)C1CC[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]1(C)CCC(OC(C)=O)C(C)(C)[C@@H]1CC3=O

InChI Key InChIKey=JIKRXLHICUVFAL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50188390   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 144nMAssay Description:Inhibition of human recombinant 11-beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of GR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibition of human recombinant 11betaHSD2 transfected in intact HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of human recombinant 17-beta-HSD2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 2.10E+4nMAssay Description:Antagonist activity against MRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant 11-beta-HSD1 transfected in intact HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50188390(4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentame...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of GR-mediated transactivation of galactosidase reporter gene in HEK293 cells in absence of 11betaHSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed