BDBM50187721 CHEMBL3828092

SMILES Fc1ccc(Nc2ncnc3ccc(cc23)-c2cnn(c2)C2CCNCC2)cc1Cl

InChI Key InChIKey=UIVCMCJROZMDFB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187721   

TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187721(CHEMBL3828092)
Affinity DataIC50: 32nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187721(CHEMBL3828092)
Affinity DataIC50: 39nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187721(CHEMBL3828092)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R/T790M double mutant (668-1210 residues) expressed in baculovirus system by z-lyte a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187721(CHEMBL3828092)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cytoplasmic His-tagged human ErbB2 expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187721(CHEMBL3828092)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of cytoplasmic GST-tagged human ErbB4 expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed