BDBM50187719 CHEMBL3828021

SMILES Cn1cc(cn1)-c1ccc2ncnc(Nc3cccc(c3)C#C)c2c1

InChI Key InChIKey=GJDYHVMPMKOHGG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187719   

TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187719(CHEMBL3828021)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187719(CHEMBL3828021)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187719(CHEMBL3828021)
Affinity DataIC50: 590nMAssay Description:Inhibition of cytoplasmic His-tagged human ErbB2 expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187719(CHEMBL3828021)
Affinity DataIC50: 782nMAssay Description:Inhibition of cytoplasmic GST-tagged human ErbB4 expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50187719(CHEMBL3828021)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R/T790M double mutant (668-1210 residues) expressed in baculovirus system by z-lyte a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed