BDBM50187379 CHEMBL379984::N-(3-{4-[4-(2-methyl-propane-1-sulfonylamino)-butyl]-piperazin-1-yl}-phenyl)-acetamide

SMILES CC(C)CS(=O)(=O)NCCCCN1CCN(CC1)c1cccc(NC(C)=O)c1

InChI Key InChIKey=UKUXMAFSBAOKLA-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187379   

Target5-hydroxytryptamine receptor 1A(Human)
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187379(N-(3-{4-[4-(2-methyl-propane-1-sulfonylamino)-buty...)
Affinity DataEC50:  60nMAssay Description:Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187379(N-(3-{4-[4-(2-methyl-propane-1-sulfonylamino)-buty...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of hERG potassium channel in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187379(N-(3-{4-[4-(2-methyl-propane-1-sulfonylamino)-buty...)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187379(N-(3-{4-[4-(2-methyl-propane-1-sulfonylamino)-buty...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Predix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50187379(N-(3-{4-[4-(2-methyl-propane-1-sulfonylamino)-buty...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to D2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed