BDBM50187351 Bis-(5-hydroxy-1H-indol-2-yl)-methanone::CHEMBL377193

SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1

InChI Key InChIKey=NIMIWWQLOGNYHD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50187351   

TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 100nMAssay Description:Antiproliferative activity against mouse 32Dcl3 cell line expressing FLT3-ITDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 100nMAssay Description:Antiproliferative activity against mouse 32Dcl3 cell line expressing wild-type FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wild-type KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 171nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of oncogenic Bcr-Abl kinase in K562 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50: 40nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed