BDBM50186850 2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(3'-methanesulfonyl-biphenyl-4-yl)-methyl]-5-fluoro-6-trifluoromethyl-1H-benzoimidazole::CHEMBL378261

SMILES CS(=O)(=O)c1cccc(c1)-c1ccc(cc1)C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)=C1CCN(CC2CC2)CC1

InChI Key InChIKey=XEGVCTLTXFUGRJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50186850   

TargetMelanin-concentrating hormone receptor 1(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50186850(2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(3'-m...)
Affinity DataIC50: 132nMAssay Description:Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50186850(2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(3'-m...)
Affinity DataKi:  132nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed