BDBM50186571 CHEMBL211896::trans-3-(4-chlorophenylsulfonyl)-3-(2,5-difluorophenyl)cyclohexanecarbaldehyde

SMILES Fc1ccc(F)c(c1)[C@@]1(CCC[C@@H](C1)C=O)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=MRNWWQISTSVGSE-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186571   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50186571(trans-3-(4-chlorophenylsulfonyl)-3-(2,5-difluoroph...)Copy SMILESCopy InChI

Affinity DataIC50: 55nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
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